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Reactivity | Human Mouse Rat Monkey |
Tested applications | WB IHC IF IP FC |
Recommended Dilution | WB 1:1000 - 1:4000 IHC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:20 - 1:50 FC 1:20 - 1:50 |
Calculated MW | 35kd |
Observed MW | Refer to Figures |
Immunogen | A synthetic peptide of human CREB1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | hikq |
Synonym | CREB ; CREB1; CREB 1 |
CREB1 is a bZIP transcription factor that activates target genes through cAMP response elements. CREB1 is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB1 is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB1 is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB1 signaling is involved in learning and memory in several organisms (4-6). CREB1 is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB1 is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB1 at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9).
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